The No. 1 seed Kansas City Chiefs will try to stay on track for their third straight Super Bowl victory when they host the No. 4 seed Houston Texans on Saturday during the 2025 Divisional Round NFL schedule. Kansas City earned a first-round bye after winning 15 of its first 16 games this season, while Houston is coming off a 32-12 win over the Chargers in the wild-card round. The Chiefs are 8-point home favorites in the Divisional Round NFL odds from the SportsLine Consensus. Which side of the Divisional Round NFL spreads should you back with your Divisional Round NFL parlay picks?
Saturday’s two-game slate concludes with a showdown between the Lions (-9.5) and Commanders at 8 p.m. ET. The action continues Sunday with Eagles vs. Rams (+6) and Bills vs. Ravens (-1), creating plenty of opportunities for Divisional Round NFL bets. Before you make any Divisional Round NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the Divisional Round of the 2025 NFL playoffs on a 31-15 betting hot streak on top-rated NFL picks this year — a stunning 67% success rate. Longer term, it is on a 211-143 roll on top-rated NFL picks that dates back to the 2017 season and a 65-36 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps could have seen strong returns.
Now, the model has scoured the Divisional Round NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Divisional Round NFL picks at SportsLine.
Top Divisional Round NFL picks
After simulating every game 10,000 times, the model is high on the Philadelphia Eagles (-6, 43.5) to cover against the Los Angeles Rams. Philadelphia was a 3-point road favorite when these teams met in Week 12, but the Eagles easily covered the spread in a 37-20 final. Running back Saquon Barkley set the Eagles franchise record with 255 rushing yards and two touchdowns, while wide receiver A.J. Brown had six receptions for 109 yards and a score.
Barkley has gone over 100 rushing yards in 10 of his last 12 games, including last week’s wild-card win over Green Bay. The Eagles have an elite offense that is built to win during the postseason, while the Rams are having to travel across the country for a cold-weather outdoor game. Philadelphia has too much firepower for Los Angeles to handle, and the model has the Eagles covering the spread in almost 60% of simulations. See which other NFL parlay picks to make here.
How to make NFL Divisional Round parlays
The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright, changing the course of the 2025 NFL playoffs forever. You can only see the model’s Divisional Round NFL best bets and NFL parlay at SportsLine.
What are the model’s top Divisional Round NFL picks, which underdog pulls off an upset, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Divisional Round NFL best bets from a model on an 211-143 run on top-rated picks, and find out.
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