2025 NFL season: Kansas City Chiefs schedule and toughest games

• The Kansas City Chiefs’ 2025 schedule has been released.
• The Chiefs have the third-best odds (+750) to win Super Bowl 60.
• Kansas City opens the season against the Los Angeles Chargers in Brazil on Sept. 5.

The Kansas City Chiefs’ 2024 season ended disappointingly when they lost 40-22 to the Philadelphia Eagles in Super Bowl 59 in February, and ever since the green and silver confetti fell from the rafters of Caesars Superdome in New Orleans, Chiefs fans have had their eyes set on the next season.

Well, now they know their team’s road map to make it to Super Bowl 60.

The NFL released the 2025 schedules for all 32 teams on May 14. After posting a 15-2 record in 2024, Kansas City has one of the hardest schedules in the league, facing eight teams that made the playoffs last season. The Patrick Mahomes-led Chiefs are set to play seven primetime games in 2025, starting with the season opener against the Los Angeles Chargers on Sept. 5 in Brazil.

Can the Chiefs make it to their sixth Super Bowl in seven years? Decide for yourself by analyzing the team’s full 2025 schedule below.

• Week 1: at Los Angeles Chargers – Friday, Sept. 5 at 7 p.m. CT
• Week 2: vs. Philadelphia Eagles – Sunday, Sept. 14 at 3:25 p.m. CT – Shop tickets
• Week 3: at New York Giants – Sunday, Sept. 21 at 7:20 p.m. CT – Shop tickets
• Week 4: vs. Baltimore Ravens – Sunday, Sept. 28 at 3:25 p.m. CT – Shop tickets
• Week 5: at Jacksonville Jaguars – Monday, Oct. 6 at 7:15 p.m. CT – Shop tickets
• Week 6: vs. Detroit Lions – Sunday, Oct. 12 at 7:20 p.m. CT – Shop tickets
• Week 7: vs. Las Vegas Raiders – Sunday, Oct. 19 at 12 p.m. CT – Shop tickets
• Week 8: vs. Washington Commanders – Monday, Oct. 27 at 7:15 p.m. CT – Shop tickets
• Week 9: at Buffalo Bills – Sunday, Nov. 2 at 3:25 p.m. CT – Shop tickets
• Week 10: BYE WEEK
• Week 11: at Denver Broncos – Sunday, Nov. 16 at 3:25 p.m. CT – Shop tickets
• Week 12: vs. Indianapolis Colts – Sunday, Nov. 23 at 12 p.m. CT – Shop tickets
• Week 13: Thanksgiving Day game – at Dallas Cowboys – Thursday, Nov. 27 at 3:30 p.m. CT— Shop tickets
• Week 14: vs. Houston Texans – Sunday, Dec. 7 at 7:20 p.m. CT – Shop tickets
• Week 15: vs. Los Angeles Chargers – Sunday, Dec. 14 at 12 p.m. CT – Shop tickets
• Week 16: at Tennessee Titans – Sunday, Dec. 21 at 12 p.m. CT – Shop tickets
• Week 17: Christmas Day game- vs. Denver Broncos – Thursday, Dec. 25, at 7:20 p.m. CT — Shop tickets
• Week 18: at Las Vegas Raiders – TBD – Shop tickets

Kansas City Chiefs odds to win Super Bowl 60

The Chiefs are +750 to hoist the Lombardi Trophy in 2026, tied for third with the Buffalo Bills, according to BetMGM. The only teams with better odds are the Baltimore Ravens (+700) and Philadelphia Eagles (+650).

More: Chiefs Super Bowl odds after 2025 NFL schedule release

Cooper Worth is a service/trending reporter for the Des Moines Register. Reach him at cworth@gannett.com or follow him on X @CooperAWorth.