The last time the Denver Broncos made the NFL playoff bracket, they went on to win the Super Bowl. The Broncos will open the 2025 NFL playoffs with a road tilt against the Buffalo Bills, who have won five of the last seven meetings against Denver. A rookie quarterback has won a playoff game in each of the past two seasons, but should you back Bo Nix and the Broncos with your NFL Wild Card Weekend picks? According to the latest NFL Wild Card Weekend odds, Denver is an 8.5-point underdog on the road, while the over-under for total points scored is 47.5.
The other Wild Card Weekend NFL spreads include Chargers vs. Texans (+3, 43.5), Steelers vs. Ravens (-9.5, 45.5), Packers vs. Eagles (-5.5, 46), Commanders vs. Buccaneers (-3, 50.5) and Vikings vs. Rams (+2, 47.5). Making NFL Wild Card Weekend score predictions can help form not only NFL spread picks, but also NFL over-under picks and NFL parlays. Which NFL Wild Card Weekend games will be lopsided, and which ones will play out closer to their NFL betting odds? Before you make any NFL Wild Card Weekend picks, make sure you see what SportsLine’s advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2025 NFL playoffs on an incredible 31-14 betting hot streak on top-rated NFL picks this year — a stunning 69% success rate. Longer term, it is on a 211-142 roll on top-rated NFL picks that dates back to the 2017 season and a 65-35 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns at their best sports betting app.
Now, the model has simulated every NFL Wild Card Weekend game 10,000 times. You can only see the model’s NFL exact score predictions at SportsLine.
Top NFL Wild Card Weekend picks
After diving into every game on the NFL Wild Card Weekend schedule, the model is backing the Buffalo Bills (-8.5, 47.5) to beat the Denver Broncos, 29-19. The Bills feature one of the league’s most potent offenses. Buffalo enters the 2025 NFL playoffs averaging 30.9 points per game, which ranks second in the NFL.
Quarterback Josh Allen has thrown for 3,731 yards, 28 touchdowns and six interceptions this season. He’s also racked up 531 rushing yards and 12 rushing touchdowns. In addition, the Bills have been extremely tough to beat at home, winning eight straight at Highmark Stadium.
The Broncos, meanwhile, are 4-5 on the road this season and 1-7 against the spread in their last eight meetings against the Bills. The model projects Allen will throw for more than 220 yards and 1.89 touchdowns, while Buffalo’s defense racks up 2.21 sacks on average. See the model’s other NFL Wild Card Weekend score predictions at SportsLine.
How to make NFL Wild Card Weekend score predictions
In addition, the model has locked in exact score predictions for every NFL Wild Card Weekend matchup. Nailing these results is key to making profitable NFL Wild Card Weekend picks. You can only see them at SportsLine.
Who wins each NFL Wild Card Weekend game, and which teams advance to the next round of the 2025 NFL playoffs? Visit SportsLine now to get the model’s NFL score predictions, all from the model on a 211-142 roll on top-rated NFL picks, and find out.
Where to bet on NFL games
Here are the top sportsbooks to bet on NFL games this week, along with the various NFL sportsbook promos they currently offer.
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