Tennessee vs. Missouri odds, prediction, line: 2025 college basketball picks, Feb. 5 best bets by proven model

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The No. 4 Tennessee Volunteers (18-4, 5-4 SEC) will aim for another home win over a ranked opponent when they host the No. 15 Missouri Tigers (17-4, 6-2) on Wednesday night. Tennessee was without two starters in its 64-44 win over then-No. 5 Florida on Saturday, snapping a two-game losing streak. Missouri has won six of its last seven games, including back-to-back wins over then-No. 16 Ole Miss and then-No. 14 Mississippi State. This is the lone meeting between these teams this season. 

Tipoff is set for 7 p.m. ET on Wednesday at Thompson-Boling Arena. Tennessee is favored by 10 points in the latest Tennessee vs. Missouri odds, while the over/under is 134.5 points, per SportsLine consensus. Before entering any Missouri vs. Tennessee picks, you’ll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 14 of the 2024-25 season on an 208-149 betting roll (+2275) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has set its sights on Missouri-Tennessee. You can head to SportsLine to see its picks. Here are several college basketball betting lines for the game:

  • Tennessee vs. Missouri spread: Tennessee -10
  • Tennessee vs. Missouri over/under: 134.5 points
  • Tennessee vs. Missouri money line: Tennessee: -500, Missouri: +375
  • Tennessee vs. Missouri picks: See picks here
  • Tennessee vs. Missouri streaming: FuboTV (Try for free)

Why Tennessee can cover

Tennessee is coming off arguably its most impressive win of the season, overcoming the absence of two starters in its blowout win over Florida on Saturday. Veteran point guard Zakai Zeigler was sidelined due to a knee injury, while versatile forward Igor Milicic Jr. had flu-like symptoms. They are both expected to return on Wednesday night. 

The Vols held Florida to just 24.5% shooting from the floor, despite playing with just seven scholarship players. Grad transfer Chaz Lanier leads Tennessee with 17.9 points per game, knocking down 79 3-pointers. Zeigler averages 12.3 points and a team-high 7.4 assists, while Jordan Gainey adds 11.0 points. See which team to pick here. 

Why Missouri can cover

Missouri has been one of the most surprising teams in the SEC this season, winning six of its past seven games to move into third place in the conference standings. The Tigers are coming off a pair of ranked wins over Ole Miss and Mississippi State, beating the Bulldogs by 27 points on the road on Saturday. They led by 14 points at halftime and used a 15-0 run early in the second half to put the game away. 

Caleb Grill shot 6 of 11 from 3-point range, scoring a team-high 20 points in the most decisive road win over a ranked team in school history. Grill has scored at least 20 points on five occasions this season, including each of his last two outings. The Tigers have covered the spread in seven of their last eight games, and they have covered in four of their last five games against Tennessee. See which team to pick here. 

How to make Tennessee vs. Missouri picks

The model has simulated Missouri vs. Tennessee 10,000 times and the results are in. We can tell you that the model is leaning Over, and it’s also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Tennessee vs. Missouri, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Missouri vs. Tennessee spread you need to jump on, all from the model on an 208-149 roll on top-rated college basketball picks, and find out.

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