Best College Football Spread Bets

The Week 10 college football schedule has plenty of excitement, including the matchup between the Colorado State Rams and the Nevada Wolf Pack.

Looking for an edge in college football? We break down the betting odds for each of the important matchups below.

Best spread bets in Week 10

College football odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 11:55 PM ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Pick: Take Boise State -23.5 vs. San Diego State

  • Game info: San Diego State Aztecs at Boise State Broncos
  • Projected winner: Boise State by 35.5 points
  • Game time: 8:00 PM ET
  • Game date: Nov. 1
  • TV channel: Fox Sports 1
  • Live stream: Fubo

Pick: Take Florida International -7.5 vs. New Mexico State

  • Game info: New Mexico State Aggies at Florida International Panthers
  • Projected winner: Florida International by 19.1 points
  • Game time: 7:00 PM ET
  • Game date: Oct. 29
  • TV channel: CBS Sports Network
  • Live stream: Fubo

Pick: Take Army -23.5 vs. Air Force

  • Game info: Air Force Falcons at Army Black Knights
  • Projected winner: Army by 34.7 points
  • Game time: 12:00 PM ET
  • Game date: Nov. 2
  • TV channel: CBS
  • Live stream: Paramount+ | Fubo

Pick: Take Memphis -7.5 vs. UTSA

  • Game info: Memphis Tigers at UTSA Roadrunners
  • Projected winner: Memphis by 18.0 points
  • Game time: 12:00 PM ET
  • Game date: Nov. 2
  • TV channel: ESPN2
  • Live stream: Fubo

Pick: Take Jacksonville State +1.5 vs. Liberty

  • Game info: Jacksonville State Gamecocks at Liberty Flames
  • Projected winner: Jacksonville State by 7.7 points
  • Game time: 7:00 PM ET
  • Game date: Oct. 30
  • TV channel: CBS Sports Network
  • Live stream: Fubo

Pick: Take Vanderbilt +6.5 vs. Auburn

  • Game info: Vanderbilt Commodores at Auburn Tigers
  • Projected winner: Vanderbilt by 2.5 points
  • Game time: 12:45 PM ET
  • Game date: Nov. 2
  • TV channel: SEC Network

Pick: Take Old Dominion -2.5 vs. Appalachian State

  • Game info: Old Dominion Monarchs at Appalachian State Mountaineers
  • Projected winner: Old Dominion by 11.2 points
  • Game time: 2:30 PM ET
  • Game date: Nov. 2
  • TV channel: ESPN+
  • Live stream: ESPN+

Pick: Take Indiana -7 vs. Michigan State

  • Game info: Indiana Hoosiers at Michigan State Spartans
  • Projected winner: Indiana by 15.6 points
  • Game time: 3:30 PM ET
  • Game date: Nov. 2
  • TV channel: Peacock

Pick: Take Florida +16.5 vs. Georgia

  • Game info: Florida Gators vs. Georgia Bulldogs
  • Projected winner: Georgia by 8.0 points
  • Game time: 3:30 PM ET
  • Game date: Nov. 2
  • TV channel: ABC
  • Live stream: Fubo

Pick: Take Western Kentucky -24.5 vs. Kennesaw State

  • Game info: Kennesaw State Owls at Western Kentucky Hilltoppers
  • Projected winner: Western Kentucky by 32.6 points
  • Game time: 7:30 PM ET
  • Game date: Oct. 30
  • TV channel: ESPN2
  • Live stream: Fubo

Pick: Take Baylor -3 vs. TCU

  • Game info: TCU Horned Frogs at Baylor Bears
  • Projected winner: Baylor by 10.4 points
  • Game time: 8:00 PM ET
  • Game date: Nov. 2
  • TV channel: ESPN2
  • Live stream: Fubo

Pick: Take Northwestern -1.5 vs. Purdue

  • Game info: Northwestern Wildcats at Purdue Boilermakers
  • Projected winner: Northwestern by 8.6 points
  • Game time: 12:00 PM ET
  • Game date: Nov. 2
  • TV channel: BTN
  • Live stream: Fubo

Pick: Take Iowa State -14.5 vs. Texas Tech

  • Game info: Texas Tech Red Raiders at Iowa State Cyclones
  • Projected winner: Iowa State by 21.4 points
  • Game time: 3:30 PM ET
  • Game date: Nov. 2
  • TV channel: ESPN
  • Live stream: Fubo

Pick: Take Virginia Tech -4 vs. Syracuse

  • Game info: Virginia Tech Hokies at Syracuse Orange
  • Projected winner: Virginia Tech by 10.4 points
  • Game time: 12:00 PM ET
  • Game date: Nov. 2
  • TV channel: The CW

Pick: Take Louisville +11.5 vs. Clemson

  • Game info: Louisville Cardinals at Clemson Tigers
  • Projected winner: Clemson by 5.1 points
  • Game time: 7:30 PM ET
  • Game date: Nov. 2
  • TV channel: ESPN
  • Live stream: Fubo

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