Ohio State vs. Indiana odds, prediction: 2025 college basketball picks, Jan. 17 best bets by proven model

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The Indiana Hoosiers (13-5) and Ohio State Buckeyes (10-7) are both motivated to get back on track Friday night in a Big Ten battle. Indiana is coming off consecutive losses to Iowa and Illinois, falling to seventh place in the conference standings. Ohio State has lost three of its last four games, putting the Buckeyes in 12th place in the conference. Indiana swept the season series last year, but both games were decided by six points or less. 

Tipoff is set for 8 p.m. ET on Friday at Value City Arena. Ohio State is favored by 7 points in the latest Ohio State vs. Indiana odds, while the over/under is 148 points, per SportsLine consensus. Before entering any Indiana vs. Ohio State picks, you’ll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 11 of the 2024-25 season on an 195-134 betting roll (+2882) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has set its sights on Indiana-Ohio State. You can head to SportsLine to see its picks. Here are several college basketball betting lines for the game:

  • Ohio State vs. Indiana spread: Ohio State -7
  • Ohio State vs. Indiana over/under: 148 points
  • Ohio State vs. Indiana money line: Ohio State: -312, Indiana: +249
  • Ohio State vs. Indiana picks: See picks here
  • Ohio State vs. Indiana streaming: FuboTV (Try for free)

Why Ohio State can cover

Ohio State has lost three of its last four games, but all three of those losses have come by seven points or fewer. The Buckeyes also notched a double-overtime win at Minnesota last week, as sophomore forward Devin Royal had 19 points and seven rebounds. They followed that game with losses to then-No. 15 Oregon and No. 24 Wisconsin, with both setbacks coming by just two points. 

Junior guard Bruce Thornton had 21 points in the loss to the Badgers, helping Ohio State cover the spread as a 7-point road underdog. Thornton leads the team with 17.4 points, 4.4 assists and 2.8 rebounds per game, while Royal is adding 13.8 points and 7.4 rebounds. The Buckeyes are 13-4 in their last 17 home games, and they have covered the spread in four of their last five home games against Indiana. See which team to pick here. 

Why Indiana can cover

Indiana is motivated to bounce back as well following a pair of losses to Iowa and No. 19 Illinois. The Hoosiers previously won five consecutive games, including wins over Rutgers, Penn State and USC. Their wins over the Scarlet Knights and Trojans both came by double digits, as they covered the spread in both games. 

Senior center Oumar Ballo, who was one of the most coveted players in the transfer portal this offseason, leads Indiana with 14.1 points and 10.1 rebounds per game. Junior forward Malik Reneau is adding 14.1 points, 5.9 rebounds and 2.3 assists, but he has missed the last four games due to a forearm injury. The Hoosiers have won and covered the spread in four of the last five meetings between these teams. See which team to pick here. 

How to make Ohio State vs. Indiana picks

The model has simulated Indiana vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it’s also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Ohio State vs. Indiana, and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the Indiana vs. Ohio State spread you need to jump on, all from the model on an 195-134 roll on top-rated college basketball picks, and find out.

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